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Green Tea Extract
Polyphenols --- 20% / 30% / 40% / 50% / 60% / 70%
Botanical Source :
Camellia sinensis --- young unoxidised leaves \| Nilgiris, Darjeeling & Assam, India
Key Active :
Total polyphenols incl. EGCG, EGC, ECG, EC; EGCG ≥ 45--50% of catechins at higher grades
Standardisation :
UV (Folin-Ciocalteu) for total polyphenols; HPLC for EGCG. Full 20--70% range enables precision formulation across applications.
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Mechanism of Action
The mechanistic profile of Green Tea Extract is anchored by EGCG, the most pharmacologically active catechin. (1) COMT inhibition --- EGCG inhibits catechol-O-methyltransferase, preventing norepinephrine degradation and sustaining thermogenesis and fat oxidation, the molecular basis for weight-management efficacy. (2) Nrf2 activation --- EGCG is among the most potent plant-derived Nrf2 inducers, upregulating HO-1, NQO1, and glutathione synthesis for cellular detoxification. (3) Multi-target anti-inflammatory action --- simultaneous NF-κB inhibition, COX-2 suppression, and pro-inflammatory cytokine (IL-6, TNF-α) reduction.
Top 3 Applications
1. Nutraceuticals --- Thermogenic Weight Management & Antioxidant Complexes
EGCG + caffeine synergy produces validated thermogenic activity. The 40--50% grade is standard for clinical-dose supplements. The 20--30% grades are ideal for high-volume applications where label aesthetics (milder colour and taste) are priorities.
2. Personal Care / Cosmeceuticals --- Anti-Aging, UV Photoprotection & Skin Brightening
EGCG demonstrates potent UV-protective, anti-wrinkle, anti-pigmentation, and anti-glycation activity in topical formulations. The 70% polyphenol concentrate is used in premium serums, eye creams, and antioxidant masks. Tyrosinase inhibition makes it a validated brightening active alongside Vitamin C.
3. Pharma / Oncology Support --- Anti-Proliferative & Neuroprotective Research Ingredient
Extensive preclinical literature supports EGCG-mediated apoptosis induction and angiogenesis inhibition across multiple cancer cell lines. Neuroprotective effects via BDNF upregulation and amyloid-β inhibition are under active investigation for neurodegenerative-disease-prevention applications.
Specification & Quality Benchmarks
Solvent: water / food-grade ethanol; decaffeinated option via COâ‚‚ polishing (≤ 0.1% caffeine).
EGCG content (by HPLC): grade-dependent (e.g., 70% polyphenol → EGCG ≥ 35%).
Caffeine content: standard ≤ 6%; low-caff ≤ 1%; decaff ≤ 0.1%.
Heavy metals: Pb ≤ 1.0 ppm (EU regulatory attention on Pb in high-dose EGCG --- strict control).
Pesticide residues: USP \<565\> / EU MRL-compliant.
Microbial: TPC ≤ 10³ CFU/g; Salmonella & E. coli absent.
Shelf life 24 months at ≤ 25 °C in light-protected packaging.
Synergy Map — Formulation Pairings
With natural caffeine --- classical thermogenic pairing (backed by clinical trials).
With Vitamin C (L-ascorbic acid) --- stabilises EGCG oxidation and compounds antioxidant output.
With Garcinia HCA --- thermogenic + anti-lipogenic.
With Moringa isothiocyanates --- dual Nrf2 activation for longevity/anti-pollution cosmeceutical claims.
With Moringa isothiocyanates --- dual Nrf2 activation for longevity/anti-pollution cosmeceutical claims.
Formulation Intelligence
Typical oral dose: 250--500 mg extract/day (high-EGCG grades); regulatory ceilings may apply in EU.
Topical use: 0.5--5% w/w in serum / cream.
pH stability: 3.0--6.0 (EGCG degrades above pH 7 and on oxidative exposure).
Solubility: water-soluble; for topical actives, partially soluble in propylene glycol and glycerin.
Colour: light-beige (low grades) to amber (high grades) --- formulators should plan pigmentation accordingly.
Buyer's Quick-Qualify
MOQ: 25 kg (50 kg for 70% grade). Free sample 50 g with TDS & CoA.
Lead time: 3--4 weeks standard; 5--6 weeks for decaffeinated or custom-EGCG grades.
Custom grades available from 20% up to 95% EGCG (research-grade).
Export markets served: US, EU, Japan, Korea, Australia, GCC.
Market & a Snapshot
Green tea extract market: \~USD 300 M (2024), CAGR \~8--10%. Regulatory: US --- multiple GRAS self-affirmations; EU EFSA has flagged EGCG hepatotoxicity above 800 mg/day as single dose → labelling caution required; Health Canada NHP-approved with monograph. Japan --- long-standing FOSHU ingredient.
Emerging Applications
EGCG phytosome and liposome formats scaling rapidly to improve bioavailability; emerging oncology-adjunctive research (androgen-receptor modulation in prostate-cancer prevention); anti-pollution cosmeceutical claims becoming primary driver in East-Asian topical launches.
Key Scientific References
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Hursel R et al. Obesity Reviews 2011;12:e573--e581
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Chacko SM et al. Chin Med. 2010;5:13
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Khan N & Mukhtar H. Life Sci. 2007;81:519--533
Contact & Next Steps
PHELBA Life Sciences · Technical Data Sheets, Certificates of Analysis, HPLC
chromatograms, stability studies, and 50–100 g free samples are available on
request for any SKU.
Website
Markets Served
US, EU, UK, Japan, Australia, GCC, ASEAN
All extracts manufactured at our cGMP- and ISO 9001:2015-certified partner facilities in India.
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FSSAI- and HACCP-licensed. Halal and Kosher certification available on request. Organic (NPOP / NOP / EU-Organic) variants available on select SKUs.